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X-ray Structures EM Structures

3D Repertoire X-ray Structures

A - Single Proteins:


Name Rrp40 Rrp40
Species Saccharomyces cerevisiae
Complex ID 500
Molecular description Exonuclease belonging to the Exosome complex
Publication Oddone, A., Lorentzen, E., Basquin, J., Gasch, A., Rybin, V., Conti, E., Sattler, M. Structural and Biochemical Characterization of the Yeast Exosome Component Rrp40 EMBO Reports v8 pp.63 , 2007 (PubMed)
PDB entry 2ja9
Partner 16A

Name Arc1p Arcp1
Species Saccharomyces cerevisiae
Complex ID 243
Molecular description N-terminal domain of GU4 nucleic-binding protein (export factor)
Publication Simader, H., Hothorn, M., Suck, D. Structures of the interacting domains from yeast glutamyl-tRNA synthetase and tRNA-aminoacylation and nuclear-export cofactor Arc1p reveal a novel function for an old fold. ACTA D v62 pp.1510-1519 , 2006 (PubMed)
PDB entry 2hqt
Partner 16A

Name Ynr046w/Tmr12 Ynr046w
Species Saccharomyces cerevisiae
Complex ID 065
Molecular description Zinc finger protein from the eRF1 methyltransferase complex
Publication Heurgue-Hamard, V., Graille, M., Scrima, N., Ulryck, N., Champ, S., Van Tilbeurgh, H., Buckingham, R.H. The Zinc Finger Protein Ynr046W is Plurifunctional and a Component of the Erf1 Methyltransferase in Yeast. J.Biol.Chem. v281 pp.36140 , 2006 (PubMed)
PDB entry 2j6a
Partner 3A

Name SEPT2 G domain SEPT2G
Species Homo sapiens
Complex ID 079
Molecular description Human SEPT2 G domain of the septin complex
Publication Sirajuddin, M.,  Farkasovsky, M.,  Hauer, F.,  Kuehlmann, D.,  Macara, I.G..,  Weyand, M.,  Stark, H.,  Wittinghofer, A. Structural insights into filament formation by mammalian septins Nature , 2007 (PubMed)
PDB entry 2qa5
Partner 2A

Name GAR1 Gar1
Species Saccharomyces cerevisiae
Complex ID ?
Molecular description Structure of the Gar1 domain of Naf1
Publication Leulliot, N.,  Godin, K.S.,  Hoareau-Aveilla, C.,  Quevillon-Cheruel, S.,  Varani, G.,  Henry, Y.,  Van Tilbeurgh, H. The Box H Aca Rnp Assembly Factor Naf1P Contains a Domain Homologous to Gar1P Mediating its Interaction with Cbf5P. (To be Published)
PDB entry 2v3m
Partner 3A

Name Emg1 Emg1
Species Saccharomyces cerevisiae
Complex ID ?
Molecular description The yeast ribosome synthesis factor Emg1 alpha beta knot fold methyltransferase
Publication Leulliot, N.,  Bohnsack, M.T.,  Graille, M.,  Tollervey, D.,  Van Tilbeurgh, H. The Yeast Ribosome Synthesis Factor Emg1 is a Novel Member of the Superfamily of Alpha Beta Knot Fold Methyltransferases. Nucleic Acid Res 2008
PDB entry 2v3k
Partner 3A

Name Trm8 Trm8
Species Saccharomyces cerevisiae
Complex ID 1506
Molecular description The catalytic subunit of the binary 7-methylguanosine tRNA methyltranferase complex
Publication Leulliot, N.,  Chaillet, M.,  Durand, D.,  Ulryck, N.,  Van Tilbeurgh, H. Structure of the Yeast tRNA M7G Methylation Complex Structure 2008
PDB entry 2vdv
Partner 3A

Name Dom34 Trm8
Species Saccharomyces cerevisiae
Complex ID (new)
Molecular description Protein related to translational termination factor Erf1
Publication Graille, M.,  Chaillet, M.,  Van Tilbeurgh, H. Structure of Yeast Dom34: A Protein Related to Translation Termination Factor Erf1 and Involved in No-Go Decay JBC 2008
PDB entry 2vgn
Partner 3A

B - Complexes:


Name Rpb41-Rpb42 Rpb41-Rpb42
Species Sulfolobus solfataricum
Complex ID 500
Molecular description RNase PH core of the archaeal exosome
Publication Lorentzen, E., Walter, P., Fribourg, S., Evguenieva-Hackenberg, E., Klug, G., Conti, E. The Archaeal Exosome is a Hexameric Ring with Three Catalytic Subunits Nat.Struct.Mol.Biol. v12 pp.575 , 2005 (PubMed)
PDB entry 2br2
Partner 16A

Name Rpb41-Rpb42-A5RNA Rpb41-Rpb42-A5RNA
Species Sulfolobus solfataricum
Complex ID 500
Molecular description RNase PH core of the archaeal exosome in complex with A5 RNA
Publication Lorentzen, E., Conti, E. Structural Basis of 3' End RNA Recognition and Exoribonucleolytic Cleavage by an Exosome Rnase Ph Core. Mol.Cell.Biol. v20 pp.473 , 2005 (PubMed)
PDB entry 2c38
Partner 16A

Name Pol II-RNA inhibitor Pol II-RNA inhibitor
Species Saccharomyces cerevisiae
Complex ID 145
Molecular description Complete RNA Polymerase II-RNA inhibitor complex
Publication Kettenberger, H., Eisenfuehr, A., Brueckner, F., Theis, M., Famulok, M., Cramer, P. Structure of an RNA polymerase II-RNA inhibitor complex elucidates transcription regulation by noncoding RNAs Nat.Struct.Mol.Biol. v13 pp.44-48 , 2006 (PubMed)
PDB entry 2b63
Partner 4

Name Med18/20 Med18/20
Species Saccharomyces cerevisiae
Complex ID 139
Molecular description Mediator head submodule (heterodimer)
Publication Lariviere, L., Geiger, S., Hoeppner, S., Rother, S., Strasser, K., Cramer, P. Structure and TBP binding of the Mediator head subcomplex Med8-Med18-Med20. Nat.Struct.Mol.Biol. v13 pp.895-901 , 2006 (PubMed)
PDB entry 2hzm
Partner 4

Name Med8C/18/20 Med8C/18/20
Species Saccharomyces cerevisiae
Complex ID 139
Molecular description Mediator head submodule (heterotrimer)
Publication Lariviere, L., Geiger, S., Hoeppner, S., Rother, S., Strasser, K., Cramer, P. Structure and TBP binding of the Mediator head subcomplex Med8-Med18-Med20. Nat.Struct.Mol.Biol. v13 pp.895-901 , 2006 (PubMed)
PDB entry 2hzs
Partner 4

Name Tau60-Tau91 Tau60-Tau91
Species Saccharomyces cerevisiae
Complex ID 001
Molecular description Subcomplex of yeast transcription factor IIIC
Publication Mylona, A., Fernandez-Tornero, C., Legrand, P., Haupt, M., Sentenac, A., Acker, J., Muller, C.W. Structure of the Tau60/Deltatau91 Subcomplex of Yeast Transcription Factor IIIC: Insights Into Preinitiation Complex Assembly Molecular Cell v24 pp.221 , 2006 (PubMed)
PDB entry 2j04
Partner 16B

Name MetRS-Arc1p MetRS-Arc1p
Species Saccharomyces cerevisiae
Complex ID 243
Molecular description Binary subcomplex of yeast aminoacyl-tRNA synthase
Publication Simader, H., Hothorn, M., Kohler, C., Basquin, J., Simos, G., Suck, D. Structural basis of yeast aminoacyl-tRNA synthetase complex formation revealed by crystal structures of two binary sub-complexes. Nucleic Acids Res. v34 pp.3968-3979 , 2006 (PubMed)
PDB entry 2hsn
Partner 16A

Name GluRS-Arc1p GluRS-Arc1p
Species Saccharomyces cerevisiae
Complex ID 243
Molecular description Binary subcomplex of yeast aminoacyl-tRNA synthase
Publication Simader, H., Hothorn, M., Kohler, C., Basquin, J., Simos, G., Suck, D. Structural basis of yeast aminoacyl-tRNA synthetase complex formation revealed by crystal structures of two binary sub-complexes. Nucleic Acids Res. v34 pp.3968-3979 , 2006 (PubMed)
PDB entry 2hrk
Partner 16A

Name Rpb41-Rpb42-Rpb4 Rpb41-Rpb42-Rpb4
Species Sulfolobus solfataricum
Complex ID 500
Molecular description 9-subunit archaeal exosome
Publication Lorentzen, E., Dziembowski, A., Lindner, D., Seraphin, B., Conti, E. RNA Channeling by the Archaeal Exosome EMBO Rep. May;8(5):470-6, 2007 (PubMed)
PDB entry 2ja6
Partner 3B, 16A, 18

Name Rpb41-Rpb42-Rpb4-RNA Rpb41-Rpb42-Rpb4-RNA
Species Sulfolobus solfataricum
Complex ID 500
Molecular description 9-subunit archaeal exosome in complex with RNA
Publication Lorentzen, E., Dziembowski, A., Lindner, D., Seraphin, B., Conti, E. RNA Channeling by the Archaeal Exosome EMBO Rep. May;8(5):470-6, 2007 (PubMed)
PDB entry 2jea
Partner 3B, 16A, 18

Name SEPT2/SEPT6/SEPT7 SEPT2/SEPT6/SEPT7
Species Homo sapiens
Complex ID 079
Molecular description Human septin trimer 2/6/7
Publication Sirajuddin, M.,  Farkasovsky, M.,  Hauer, F.,  Kuehlmann, D.,  Macara, I.G..,  Weyand, M.,  Stark, H.,  Wittinghofer, A. Structural insights into filament formation by mammalian septins Nature , 2007 (PubMed)
PDB entry 2qag
Partner 2A

Name Trm8/Trm82 Trm8/Trm82
Species Saccharomyces cerevisiae
Complex ID 1506
Molecular description The binary 7-methylguanosine tRNA methyltranferase complex
Publication Leulliot, N.,  Chaillet, M.,  Durand, D.,  Ulryck, N.,  Van Tilbeurgh, H. Structure of the Yeast tRNA M7G Methylation Complex Structure, 2008
PDB entry 2vdu
Partner 3A

Name INCEP/Survivin/Borealin INCEP/Survivin/Borealin
Species Homo sapiens
Complex ID (new)
Molecular description Engineered Chromosomal Passenger Complex
Publication eyaprakash, A.A.,  Klein, U.R.,  Lindner, D.,  Ebert, J.,  Nigg, E.A.,  Conti, E. (2007) Structure of a Survivin-Borealin-INCENP Core Complex Reveals How Chromosomal Passengers Travel Together. Cell
PDB entry 2qfa
Partner 2B